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科技研發Research and development
研發體系

研發體系

 山西千匯藥業有限公司和北京大學醫學部安森博公司和歐盟Synbias Pharma LLC公司結成戰略合作伙伴,已經成功引進歐盟創新抗腫瘤藥物4個品種,分別為注射用鹽酸伊達比星、注射用鹽酸表柔比星、注射用鹽酸多柔比星、注射用鹽酸吡柔比星。目前已進入生產申報階段。

藥品名稱
商品名稱:艾諾寧
通用名稱:注射用鹽酸伊達比星
英文名稱:Idarubicin Hydrochloride for Injection


成份
化學名稱:本品主要成份為鹽酸伊達比星,其化學名為4-去甲氧基柔紅霉素鹽酸鹽。 化學結構式: 分子式:C26H27NO9·HCl 分子量:533.97 輔料:乳糖
 適應癥 】急性淋巴細胞性白血病和急性非淋巴細胞性白血病。 

藥物相互作用

與其它有骨髓抑制作用的藥物合用可加重骨髓抑制。與堿性溶液將降解。與肝素合用會產生沉淀,故不要與其它藥物使用。

藥理作用

本品嵌入DNA雙鏈的堿基對之間,抑制DNA鏈的延伸、復制和轉錄,最后導致細胞死亡。新近發現,本品還可影響拓撲異構酶Ⅱ(TopⅡ)的活性。TopⅡ在維持DNA的zheng常空間結構、保證DNA復制和轉錄中具有重要作用。本品抑制該酶活性,可導致DNA裂解,通過濾過洗脫可以檢測到與蛋白質結合的DNA碎pian。本品引起的DNA損害與自由基關系不大,也不是細胞早期死亡的結果。

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3分赛车

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